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The incidence of colon cancer varies by sex. Whether women and men show differences in extent of disease, treatment, and outcomes is not well described. We used a large population-based cohort to evaluate sex differences in colon cancer. Using the Ontario Cancer Registry, all cases of colon cancer treated with surgery in Ontario during — were identified. Electronic records of treatment identified use of surgery and adjuvant chemotherapy. A Cox proportional hazards model was used to identify factors associated with overall os and cancer-specific survival css.
Stage of disease and histologic grade did not vary by sex. Surgical procedure and lymph node yield did not differ by sex. Adjusted analyses demonstrated that os [hazard ratio hr: Long-term survival after colon cancer is significantly better for women than for men, which is not explained by any substantial differences in extent of disease or treatment delivered.
Colorectal cancer crc is the 3rd most common cancer in Canada, with an estimated incidence of 25, cases in After lung cancer, crc is the 2nd most common cause of cancer death, with an estimated deaths annually in Canada 1.
Variation by sex in the incidence and outcomes of cancer is well described 2. Male sex has been associated with a higher crc incidence 3 and worse prognosis 4 — 6.
The reasons for those associations are not well described, but might be related to differences in tumour location 3 , 7 , 8 , stage at presentation 9 , and estrogen exposure 10 — Women are older at presentation 10 , 13 , present with lower-stage disease 13 , and are more likely to undergo curative surgical resection Furthermore, existing studies suggest that, compared with men, women with colon cancer experience better cancer-specific survival 3 , 9 , 13 , Although those results are intriguing, the literature on this topic is limited to institution-based studies with small sample sizes that describe cases from the s and s.